Genetic and phenotypic characterization of capsule mutants of Cryptococcus neoformans
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چکیده
منابع مشابه
Genetic and phenotypic characterization of capsule mutants of Cryptococcus neoformans.
Stable mutants with reduced capacity to produce capsules were isolated from suspensions of Cryptococcus neoformans after treatment of the wild type with a mutagen. The mutants could be assigned one of two phenotypes, hypocapsular or acapsular. Hypocapsular mutants were immunochemically and physicochemically indistinguishable from the wild type, whereas acapsular mutants lacked a major capsular ...
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Cryptococcus neoformans is a pathogenic yeast that causes meningitis in immunocompromised patients. Because iron acquisition is critical for growth of a pathogen in a host, we studied the regulation of the ferric reductase and ferrous uptake system of this organism. We isolated 18 mutants, representing four independent loci, with dysregulated ferric reductase. The mutant strains had >10-fold hi...
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ln this study several tests showed that high level of iron either in sera from patients with rheumatoid arthritis, th alassaemia major or in standard iron solutions, have inhibitory effect oil capsule production of cryptococcus neotormans. this work is concerned with the probable role of iron in pigeon's natural resistance against cryptococcal infection: no protease activity was detected in eit...
متن کاملCryptococcus neoformans. I. Nonencapsulated mutants.
Seven nonencapsulated mutants of Cryptococcus neoformans were isolated from an encapsulated strain of human origin. Initially, the mutants were avirulent for mice. After several months of subculturing, six of the seven isolates reverted to the encapsulated state and possessed varying degrees of virulence. The results of these experiments suggest that a strong correlation exists between the pres...
متن کاملSpatial and temporal sequence of capsule construction in Cryptococcus neoformans.
The pathogenic yeast Cryptococcus neoformans is distinguished by an extensive polysaccharide capsule, which impedes host defences and is absolutely required for fungal virulence. Despite the biological importance of the capsule, nothing is known about how it is assembled. Substantial capsule growth occurs in two distinct situations relevant to cryptococcal pathogenesis: formation of new buds an...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1982
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.150.3.1292-1296.1982